Retatrutide is called a “triple agonist” because it acts on three different hormone receptors in the body:
GLP-1 receptor → reduces appetite, slows digestion, stabilizes blood sugar
GIP receptor → improves insulin sensitivity and helps the body burn calories more efficiently
Glucagon receptor → increases fat burning and boosts energy use
By targeting all three, Retatrutide works even more powerfully than older GLP-1 medications like Semaglutide or Tirzepatide.